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NSAR
Hemmen NSAR die selektiv wirken bei einer RMR am footprint die Heilung am Knochen? Wenn ja gibt es dazu Daten bei welcher Dauer und dosis diese negative Auswirkungen haben? Bzw bei welcher Dosis/Dauer das der Fall ist?
Grüße
Dominik
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4 Antworten
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Hallo Dominik,
bei einer konservativ oder operativ versorgten Rotatorenmanschettenruptur?
LG
Tobias
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Operativ versorgt.
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Hi Dominik,
schau mal hier: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604538/
Results:
A total of 13 studies, including three clinical and 10 basic science studies, were included. The overall methodological quality of the included clinical studies was poor, while assessment of the basic science studies revealed consistent areas at high or unclear risk of bias. Of the included clinical studies, a single study reported a higher rate of rotator cuff repair failure with selective (COX-2) NSAID use compared with non-selective NSAID use, while no clinical failures were noted with NSAID use following distal biceps tendon repair. Basic science studies had heterogeneous outcome reporting. A subgroup analysis of homogeneous animal studies revealed no significant effect of all NSAIDs (Standard Mean Difference [SMD] -1.05, 95% Confidence Interval [CI] -2.39-0.30, p=0.13) or non-selective NSAIDs on load to failure (SMD -0.62, 95% CI -1.26-0.02, p=0.06).
Conclusions:
The current literature does not provide sufficient evidence for or against the use of NSAIDs following acute injury or surgical repair of the tendon-bone interface.
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Super vielen Dank. Schönes Wochenende.
Grüße
Dominik