• Veröffentlich von Dominik Migsch on 29. März 2023 at 19:35

    Hemmen NSAR die selektiv wirken bei einer RMR am footprint die Heilung am Knochen? Wenn ja gibt es dazu Daten bei welcher Dauer und dosis diese negative Auswirkungen haben? Bzw bei welcher Dosis/Dauer das der Fall ist?

    Grüße

    Dominik

    Dominik Migsch hat geantwortet vor 1 year, 2 months aktiv. 2 Mitglieder · 4 Antworten
  • 4 Antworten
  • Tobias Saueressig

    Mitglied
    30. März 2023 at 10:34

    Hallo Dominik,

    bei einer konservativ oder operativ versorgten Rotatorenmanschettenruptur?

    LG

    Tobias

  • Dominik Migsch

    Mitglied
    30. März 2023 at 11:13

    Operativ versorgt.

  • Tobias Saueressig

    Mitglied
    31. März 2023 at 8:47

    Hi Dominik,

    schau mal hier: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604538/


    Results:

    A total of 13 studies, including three clinical and 10 basic science studies, were included. The overall methodological quality of the included clinical studies was poor, while assessment of the basic science studies revealed consistent areas at high or unclear risk of bias. Of the included clinical studies, a single study reported a higher rate of rotator cuff repair failure with selective (COX-2) NSAID use compared with non-selective NSAID use, while no clinical failures were noted with NSAID use following distal biceps tendon repair. Basic science studies had heterogeneous outcome reporting. A subgroup analysis of homogeneous animal studies revealed no significant effect of all NSAIDs (Standard Mean Difference [SMD] -1.05, 95% Confidence Interval [CI] -2.39-0.30, p=0.13) or non-selective NSAIDs on load to failure (SMD -0.62, 95% CI -1.26-0.02, p=0.06).

    Conclusions:

    The current literature does not provide sufficient evidence for or against the use of NSAIDs following acute injury or surgical repair of the tendon-bone interface.

  • Dominik Migsch

    Mitglied
    31. März 2023 at 10:04

    Super vielen Dank. Schönes Wochenende.

    Grüße

    Dominik

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